Open AccessEffects of High Glucose-Induced Cx43 Downregulation on Occludin and ZO-1 Expression and Tight Junction Barrier Function in Retinal Endothelial Cells
Author(s) -
Thomas Tien,
Kevin Barrette,
Argyrios Chronopoulos,
Sayon Roy
Publication year - 2013
Publication title -
investigative ophthalmology and visual science
Language(s) - English
Resource type - Journals
eISSN - 1552-5783
pISSN - 0146-0404
DOI - 10.1167/iovs.13-11763
Subject(s) - occludin , connexin , downregulation and upregulation , transfection , gap junction , tight junction , microbiology and biotechnology , cell junction , chemistry , western blot , cell culture , biology , intracellular , cell , biochemistry , genetics , gene
To investigate whether high glucose (HG)-induced downregulation of connexin 43 (Cx43), a gap junction protein, alters ZO-1 and occludin expression and cell monolayer permeability.
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