Development, Composition, and Structural Arrangements of the Ciliary Zonule of the Mouse | Zendy

Yanrong Shi | Zendy; Yidong Tu | Zendy; Alicia María | Zendy; Robert P. Mecham | Zendy; Steven Bassnett | Zendy

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Development, Composition, and Structural Arrangements of the Ciliary Zonule of the Mouse

Author(s) -

Yanrong Shi,

Yidong Tu,

Alicia María,

Robert P. Mecham,

Steven Bassnett

Publication year - 2013

Publication title -

investigative ophthalmology and visual science

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.935

H-Index - 218

eISSN - 1552-5783

pISSN - 0146-0404

DOI - 10.1167/iovs.13-11619

Subject(s) - fibrillin , ciliary processes , ciliary body , microfibril , lens (geology) , anatomy , cornea , iris (biosensor) , microbiology and biotechnology , marfan syndrome , biology , pathology , medicine , ophthalmology , extracellular matrix , cellulose , paleontology , biochemistry , computer security , surgery , computer science , biometrics

Here, we examined the development, composition, and structural organization of the ciliary zonule of the mouse. Fibrillin 1, a large glycoprotein enriched in force-bearing tissues, is a prominent constituent of the mouse zonule. In humans, mutations in the gene for fibrillin 1 (FBN1) underlie Marfan syndrome (MS), a disorder characterized by lens dislocation and other ocular symptoms.

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