Open AccessOxidative and Endoplasmic Reticulum Stresses Mediate Apoptosis Induced by Modified LDL in Human Retinal Müller Cells
Author(s) -
Mingyuan Wu,
Shuai Yang,
Michael H. Elliott,
Dongxu Fu,
Ken Wilson,
Jing Zhang,
Mei Du,
Junping Chen,
Timothy J. Lyons
Publication year - 2012
Publication title -
investigative ophthalmology and visual science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.935
H-Index - 218
eISSN - 1552-5783
pISSN - 0146-0404
DOI - 10.1167/iovs.12-9910
Subject(s) - unfolded protein response , oxidative stress , viability assay , apoptosis , kdel , endoplasmic reticulum , chemistry , tunel assay , superoxide dismutase , microbiology and biotechnology , biology , biochemistry , golgi apparatus
We previously showed that extravasated, modified LDL is implicated in pericyte loss in diabetic retinopathy (DR). Here, we investigate whether modified LDL induces apoptosis in retinal Müller glial cells.