Oxidative and Endoplasmic Reticulum Stresses Mediate Apoptosis Induced by Modified LDL in Human Retinal Müller Cells | Zendy

Mingyuan Wu | Zendy; Shihe Yang | Zendy; Michael H. Elliott | Zendy; Dongxu Fu | Zendy; Kenneth Wilson | Zendy; Jing Zhang | Zendy; Mei Du | Zendy; Junping Chen | Zendy; Timothy J. Lyons | Zendy

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Oxidative and Endoplasmic Reticulum Stresses Mediate Apoptosis Induced by Modified LDL in Human Retinal Müller Cells

Author(s) -

Mingyuan Wu,

Shihe Yang,

Michael H. Elliott,

Dongxu Fu,

Kenneth Wilson,

Jing Zhang,

Mei Du,

Junping Chen,

Timothy J. Lyons

Publication year - 2012

Publication title -

investigative ophthalmology and visual science

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.935

H-Index - 218

eISSN - 1552-5783

pISSN - 0146-0404

DOI - 10.1167/iovs.12-9910

Subject(s) - unfolded protein response , oxidative stress , viability assay , apoptosis , kdel , endoplasmic reticulum , chemistry , tunel assay , superoxide dismutase , microbiology and biotechnology , biology , biochemistry , golgi apparatus

We previously showed that extravasated, modified LDL is implicated in pericyte loss in diabetic retinopathy (DR). Here, we investigate whether modified LDL induces apoptosis in retinal Müller glial cells.

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