Interleukin-6 Production in CD40-Engaged Fibrocytes in Thyroid-Associated Ophthalmopathy: Involvement of Akt and NF-κB | Zendy

Erin F. Gillespie | Zendy; Nupur Raychaudhuri | Zendy; K. Papageorgiou | Zendy; Stephen Atkins | Zendy; Ying Lu | Zendy; Laya K. Charara | Zendy; Tünde Mester | Zendy; Terry J. Smith | Zendy; Raymond S. Douglas | Zendy

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Interleukin-6 Production in CD40-Engaged Fibrocytes in Thyroid-Associated Ophthalmopathy: Involvement of Akt and NF-κB

Author(s) -

Erin F. Gillespie,

Nupur Raychaudhuri,

K. Papageorgiou,

Stephen Atkins,

Ying Lu,

Laya K. Charara,

Tünde Mester,

Terry J. Smith,

Raymond S. Douglas

Publication year - 2012

Publication title -

investigative ophthalmology and visual science

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.935

H-Index - 218

eISSN - 1552-5783

pISSN - 0146-0404

DOI - 10.1167/iovs.12-9861

Subject(s) - protein kinase b , fibrocyte , medicine , thyroid , cancer research , endocrinology , biology , pathology , signal transduction , microbiology and biotechnology

CD40-CD40 ligand (CD40L) interactions appear to play pathogenic roles in autoimmune disease. Here we quantify CD40 expression on fibrocytes, circulating, and bone marrow-derived progenitor cells. The functional consequences of CD40 ligation are determined since these may promote tissue remodeling linked with thyroid-associated ophthalmopathy (TAO).

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