Open AccessInterleukin-6 Production in CD40-Engaged Fibrocytes in Thyroid-Associated Ophthalmopathy: Involvement of Akt and NF-κB
Author(s) -
Erin F. Gillespie,
Nupur Raychaudhuri,
Κ. Παπαγεωργίου,
Stephen Atkins,
Ying Lu,
Laya K. Charara,
Tünde Mester,
Terry J. Smith,
Raymond S. Douglas
Publication year - 2012
Publication title -
investigative ophthalmology and visual science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.935
H-Index - 218
eISSN - 1552-5783
pISSN - 0146-0404
DOI - 10.1167/iovs.12-9861
Subject(s) - protein kinase b , fibrocyte , medicine , thyroid , cancer research , endocrinology , biology , pathology , signal transduction , microbiology and biotechnology
CD40-CD40 ligand (CD40L) interactions appear to play pathogenic roles in autoimmune disease. Here we quantify CD40 expression on fibrocytes, circulating, and bone marrow-derived progenitor cells. The functional consequences of CD40 ligation are determined since these may promote tissue remodeling linked with thyroid-associated ophthalmopathy (TAO).