Impact of Repeated Topical-Loaded Manganese-Enhanced MRI on the Mouse Visual System | Zendy

ShuWei Sun | Zendy; Tiffany Thiel | Zendy; HsiaoFang Liang | Zendy

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Impact of Repeated Topical-Loaded Manganese-Enhanced MRI on the Mouse Visual System

Author(s) -

ShuWei Sun,

Tiffany Thiel,

HsiaoFang Liang

Publication year - 2012

Publication title -

investigative ophthalmology and visual science

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.935

H-Index - 218

eISSN - 1552-5783

pISSN - 0146-0404

DOI - 10.1167/iovs.12-9715

Subject(s) - optic nerve , magnetic resonance imaging , medicine , repeated measures design , ophthalmology , pathology , anesthesia , chemistry , radiology , statistics , mathematics

Optic nerve degeneration in diseases such as glaucoma and multiple sclerosis evolves in months to years. The use of Mn(2+)-Enhanced Magnetic Resonance Imaging (MEMRI) in a time-course study may provide new insights into the disease progression. Previously, we demonstrated the feasibility of using a topical administration for Mn(2+) delivery to the visual system. This study is to evaluate the impact of biweekly or monthly repeated Mn(2+) topical administration and the pH levels of the Mn(2+) solutions for MEMRI on the mouse visual pathway.

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