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Involvement of Periostin in Regression of Hyaloidvascular System during Ocular Development
Author(s) -
Mitsuru Arima,
Shigeo Yoshida,
Takahito Nakama,
Keijiro Ishikawa,
Shintaro Nakao,
Takeru Yoshimura,
Ryo Asato,
Yukio Sassa,
Takeshi Kita,
Hiroshi Enaida,
Yuji Oshima,
Akira Matsuda,
Akira Kudō,
Tatsuro Ishibashi
Publication year - 2012
Publication title -
investigative ophthalmology and visual science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.935
H-Index - 218
eISSN - 1552-5783
pISSN - 0146-0404
DOI - 10.1167/iovs.12-9684
Subject(s) - periostin , matricellular protein , pathology , immunohistochemistry , fibronectin , angiogenesis , medicine , biology , cancer research , extracellular matrix , microbiology and biotechnology
A timely regression of the hyaloid vascular system (HVS) is required for the normal ocular development. Although macrophages have a critical role in this process, the exact mechanism remains undetermined. Periostin is a matricellular protein involved in tissue and vascular remodeling. The purpose of our study was to determine whether periostin is involved in the HVS regression.

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