Overexpression of SPARC in Human Trabecular Meshwork Increases Intraocular Pressure and Alters Extracellular Matrix | Zendy

DongJin Oh | Zendy; Min Hyung Kang | Zendy; Yen Hoong Ooi | Zendy; Kyu Ryong Choi | Zendy; E. Helene Sage | Zendy; Douglas J. Rhee | Zendy

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Overexpression of SPARC in Human Trabecular Meshwork Increases Intraocular Pressure and Alters Extracellular Matrix

Author(s) -

DongJin Oh,

Min Hyung Kang,

Yen Hoong Ooi,

Kyu Ryong Choi,

E. Helene Sage,

Douglas J. Rhee

Publication year - 2013

Publication title -

investigative ophthalmology and visual science

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.935

H-Index - 218

eISSN - 1552-5783

pISSN - 0146-0404

DOI - 10.1167/iovs.12-11362

Subject(s) - trabecular meshwork , fibronectin , zymography , extracellular matrix , matricellular protein , laminin , matrix metalloproteinase , myocilin , collagen vi , intraocular pressure , chemistry , extracellular , microbiology and biotechnology , biology , ophthalmology , medicine , biochemistry

Intraocular pressure (IOP) regulation is largely unknown. SPARC-null mice demonstrate a lower IOP resulting from increased outflow. SPARC is a matricellular protein often associated with fibrosis. We hypothesized that SPARC overexpression would alter IOP by affecting extracellular matrix (ECM) synthesis and/or turnover in the trabecular meshwork (TM).

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