Unique Response Profile of Trabecular Meshwork Cells to the Novel Selective Glucocorticoid Receptor Agonist, GW870086X | Zendy

W. Daniel Stamer | Zendy; Emely A. Hoffman | Zendy; Edit Kurali | Zendy; Achim H.P. Krauss | Zendy

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Unique Response Profile of Trabecular Meshwork Cells to the Novel Selective Glucocorticoid Receptor Agonist, GW870086X

Author(s) -

W. Daniel Stamer,

Emely A. Hoffman,

Edit Kurali,

Achim H.P. Krauss

Publication year - 2013

Publication title -

investigative ophthalmology and visual science

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.935

H-Index - 218

eISSN - 1552-5783

pISSN - 0146-0404

DOI - 10.1167/iovs.12-11298

Subject(s) - trabecular meshwork , myocilin , endocrinology , glucocorticoid receptor , medicine , fibronectin , chemistry , receptor , glucocorticoid , dexamethasone , agonist , secretion , cell , biology , glaucoma , biochemistry , neuroscience

Glucocorticoid (GC)-induced glaucoma is an undesirable side effect of traditional GCs. Ocular hypertension responsible for GC-induced glaucoma is due to alterations in conventional outflow homeostasis. The present study evaluates a novel selective GC receptor agonist (SEGRA), GW870086X, in two different in vitro models of the human conventional outflow pathway.

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