Open AccessUnique Response Profile of Trabecular Meshwork Cells to the Novel Selective Glucocorticoid Receptor Agonist, GW870086X
Author(s) -
W. Daniel Stamer,
Emely A. Hoffman,
Edit Kurali,
Achim H.-P. Krauss
Publication year - 2013
Publication title -
investigative ophthalmology and visual science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.935
H-Index - 218
eISSN - 1552-5783
pISSN - 0146-0404
DOI - 10.1167/iovs.12-11298
Subject(s) - trabecular meshwork , myocilin , endocrinology , glucocorticoid receptor , medicine , fibronectin , chemistry , receptor , glucocorticoid , dexamethasone , agonist , secretion , cell , biology , glaucoma , biochemistry , neuroscience
Glucocorticoid (GC)-induced glaucoma is an undesirable side effect of traditional GCs. Ocular hypertension responsible for GC-induced glaucoma is due to alterations in conventional outflow homeostasis. The present study evaluates a novel selective GC receptor agonist (SEGRA), GW870086X, in two different in vitro models of the human conventional outflow pathway.