Open AccessSubretinal Implantation of Retinal Pigment Epithelial Cells Derived From Human Embryonic Stem Cells: Improved Survival When Implanted as a Monolayer
Author(s) -
Bruno Diniz,
Padmaja B. Thomas,
Biju Thomas,
Ramiro Ribeiro,
Yuntao Hu,
Rodrigo Brant,
Ashish Ahuja,
Danhong Zhu,
Laura Liu,
Michael Koss,
Maurício Maia,
Gerald J. Chader,
David R. Hinton,
Mark S. Humayun
Publication year - 2013
Publication title -
investigative ophthalmology and visual science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.935
H-Index - 218
eISSN - 1552-5783
pISSN - 0146-0404
DOI - 10.1167/iovs.12-11239
Subject(s) - embryonic stem cell , retinal , stem cell , retinal pigment epithelium , pigment , microbiology and biotechnology , retina , monolayer , biology , anatomy , chemistry , ophthalmology , medicine , neuroscience , biochemistry , gene , organic chemistry
To evaluate cell survival and tumorigenicity of human embryonic stem cell-derived retinal pigment epithelium (hESC-RPE) transplantation in immunocompromised nude rats. Cells were transplanted as a cell suspension (CS) or as a polarized monolayer plated on a parylene membrane (PM).