Open AccessRole of Substratum Stiffness in Modulating Genes Associated with Extracellular Matrix and Mechanotransducers YAP and TAZ
Author(s) -
Vijay Krishna Raghunathan,
Joshua T. Morgan,
Britta Dreier,
Christopher M. Reilly,
Sara M. Thomasy,
Joshua A. Wood,
Irene Ly,
Binh C. Tuyen,
Marissa L. Hughbanks,
Christopher J. Murphy,
Paul Russell
Publication year - 2012
Publication title -
investigative ophthalmology and visual science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.935
H-Index - 218
eISSN - 1552-5783
pISSN - 0146-0404
DOI - 10.1167/iovs.12-11007
Subject(s) - trabecular meshwork , downregulation and upregulation , ctgf , extracellular matrix , microbiology and biotechnology , hippo signaling pathway , gene silencing , wnt signaling pathway , myocilin , extracellular , cyr61 , biology , gene expression , chemistry , signal transduction , gene , glaucoma , growth factor , biochemistry , receptor , neuroscience
Primary open-angle glaucoma is characterized by increased resistance to aqueous humor outflow and a stiffer human trabecular meshwork (HTM). Two Yorkie homologues, Yes-associated protein (YAP) and transcriptional coactivator with PDZ-binding motif, encoded by WWTR1 (TAZ), are mechanotransducers of the extracellular-microenvironment and coactivators of transcription. Here, we explore how substratum stiffness modulates the YAP/TAZ pathway and extracellular matrix genes in HTM cells and how this may be play a role in the onset and progression of glaucoma.
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