Excitotoxicity Upregulates SARM1 Protein Expression and Promotes Wallerian-Like Degeneration of Retinal Ganglion Cells and Their Axons | Zendy

Charlotte Massoll | Zendy; Wasym Mando | Zendy; Shravan K. Chintala | Zendy

Open Access

Excitotoxicity Upregulates SARM1 Protein Expression and Promotes Wallerian-Like Degeneration of Retinal Ganglion Cells and Their Axons

Author(s) -

Charlotte Massoll,

Wasym Mando,

Shravan K. Chintala

Publication year - 2013

Publication title -

investigative ophthalmology and visual science

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.935

H-Index - 218

eISSN - 1552-5783

pISSN - 0146-0404

DOI - 10.1167/iovs.12-10973

Subject(s) - excitotoxicity , wallerian degeneration , microbiology and biotechnology , degeneration (medical) , giant retinal ganglion cells , ganglion , retinal ganglion cell , chemistry , neuroscience , biology , retina , ophthalmology , apoptosis , medicine , programmed cell death , biochemistry

This study investigated the role of sterile alpha/Armadillo/Toll-Interleukin receptor homology domain 1 protein (SARM1) in Wallerian-like degeneration of retinal ganglion cells (RGCs) and their axons after inducing excitotoxicity.

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