MicroRNA-200b Downregulates Oxidation Resistance 1 (Oxr1) Expression in the Retina of Type 1 Diabetes Model | Zendy

Anne R. Murray | Zendy; Qian Chen | Zendy; Yusuke Takahashi | Zendy; Kelu Zhou | Zendy; Kyoungmin Park | Zendy; Jianxing Ma | Zendy

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MicroRNA-200b Downregulates Oxidation Resistance 1 (Oxr1) Expression in the Retina of Type 1 Diabetes Model

Author(s) -

Anne R. Murray,

Qian Chen,

Yusuke Takahashi,

Kelu Zhou,

Kyoungmin Park,

Jianxing Ma

Publication year - 2013

Publication title -

investigative ophthalmology and visual science

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.935

H-Index - 218

eISSN - 1552-5783

pISSN - 0146-0404

DOI - 10.1167/iovs.12-10921

Subject(s) - microrna , retina , resistance (ecology) , chemistry , microbiology and biotechnology , ophthalmology , biology , medicine , neuroscience , gene , biochemistry , ecology

MicroRNAs (miRNAs) are known to participate in post-transcriptional regulation of gene expression and are involved in multiple pathogenic processes. Here, we identified miRNA expression changes in the retinas of Akita mice, a genetic model of type 1 diabetes, and investigated the potential role of miRNA in diabetic retinopathy.

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