Open AccessMicroRNA-200b Downregulates Oxidation Resistance 1 (Oxr1) Expression in the Retina of Type 1 Diabetes Model
Author(s) -
Anne R. Murray,
Qian Chen,
Yusuke Takahashi,
Kelu Zhou,
Kyoungmin Park,
Jian Xing
Publication year - 2013
Publication title -
investigative ophthalmology and visual science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.935
H-Index - 218
eISSN - 1552-5783
pISSN - 0146-0404
DOI - 10.1167/iovs.12-10921
Subject(s) - microrna , retina , resistance (ecology) , chemistry , microbiology and biotechnology , ophthalmology , biology , medicine , neuroscience , gene , biochemistry , ecology
MicroRNAs (miRNAs) are known to participate in post-transcriptional regulation of gene expression and are involved in multiple pathogenic processes. Here, we identified miRNA expression changes in the retinas of Akita mice, a genetic model of type 1 diabetes, and investigated the potential role of miRNA in diabetic retinopathy.