Epigenetic Modification ofSod2in the Development of Diabetic Retinopathy and in the Metabolic Memory: Role of Histone Methylation | Zendy

Qing Peter Wild Zhong | Zendy; Renu A. Kowluru | Zendy

Open Access

Epigenetic Modification ofSod2in the Development of Diabetic Retinopathy and in the Metabolic Memory: Role of Histone Methylation

Author(s) -

Qing Peter Wild Zhong,

Renu A. Kowluru

Publication year - 2012

Publication title -

investigative ophthalmology and visual science

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.935

H-Index - 218

eISSN - 1552-5783

pISSN - 0146-0404

DOI - 10.1167/iovs.12-10854

Subject(s) - sod2 , epigenetics , histone methylation , endocrinology , histone , methylation , medicine , diabetic retinopathy , biology , dna methylation , chemistry , diabetes mellitus , gene expression , biochemistry , oxidative stress , superoxide dismutase , gene

Mitochondrial superoxide levels are elevated in the retina in diabetes, and their scavenging enzyme, MnSOD, becomes subnormal. The objective of this study is to investigate the role of histone methylation of Sod2, the gene that encodes MnSOD, in the development of diabetic retinopathy and in the metabolic memory phenomenon associated with its continued progression after termination of hyperglycemia.

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