Open AccessProtective Effect of Carnosic Acid, a Pro-Electrophilic Compound, in Models of Oxidative Stress and Light-Induced Retinal Degeneration
Author(s) -
Tayebeh Rezaie,
Scott R. McKercher,
Kunio Kosaka,
Masaaki Seki,
Larry A. Wheeler,
Veena Viswanath,
Teresa Chun,
Rabina Joshi,
Marcos Valencia,
Shunsuke Sasaki,
Terumasa Tozawa,
Tsuyoshi Satoh,
Stuart A. Lipton
Publication year - 2012
Publication title -
investigative ophthalmology and visual science
Language(s) - English
Resource type - Journals
eISSN - 1552-5783
pISSN - 0146-0404
DOI - 10.1167/iovs.12-10793
Subject(s) - oxidative stress , retina , retinal degeneration , outer nuclear layer , neuroprotection , retinal , carnosic acid , antioxidant , retinitis pigmentosa , erg , pharmacology , chemistry , visual phototransduction , in vivo , electroretinography , retinal pigment epithelium , microbiology and biotechnology , biochemistry , biology , neuroscience , genetics
The herb rosemary has been reported to have antioxidant and anti-inflammatory activity. We have previously shown that carnosic acid (CA), present in rosemary extract, crosses the blood-brain barrier to exert neuroprotective effects by upregulating endogenous antioxidant enzymes via the Nrf2 transcriptional pathway. Here we investigated the antioxidant and neuroprotective activity of CA in retinal cell lines exposed to oxidative stress and in a rat model of light-induced retinal degeneration (LIRD).