NLRP3 Inflammasome Activation in Retinal Pigment Epithelial Cells by Lysosomal Destabilization: Implications for Age-Related Macular Degeneration | Zendy

Wen Allen Tseng | Zendy; Thuzar Thein | Zendy; Kati Kinnunen | Zendy; Kameran Lashkari | Zendy; Meredith S. Gregory | Zendy; Patricia A. D’Amore | Zendy; Bruce R. Ksander | Zendy

Open Access

NLRP3 Inflammasome Activation in Retinal Pigment Epithelial Cells by Lysosomal Destabilization: Implications for Age-Related Macular Degeneration

Author(s) -

Wen Allen Tseng,

Thuzar Thein,

Kati Kinnunen,

Kameran Lashkari,

Meredith S. Gregory,

Patricia A. D’Amore,

Bruce R. Ksander

Publication year - 2012

Publication title -

investigative ophthalmology and visual science

Language(s) - English

Resource type - Journals

eISSN - 1552-5783

pISSN - 0146-0404

DOI - 10.1167/iovs.12-10655

Subject(s) - inflammasome , macular degeneration , retinal pigment epithelium , caspase 1 , pathogenesis , caspase , apoptosis , cytotoxicity , retinal , microbiology and biotechnology , geographic atrophy , chemistry , programmed cell death , biology , inflammation , medicine , immunology , biochemistry , in vitro , ophthalmology

To evaluate the effect of lysosomal destabilization on NLRP3 inflammasome activation in RPE cells and to investigate the mechanisms by which inflammasome activation may contribute to the pathogenesis of age-related macular degeneration (AMD).

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