Alterations of Retinal Vasculature in Cystathionine-Beta-Synthase Mutant Mice, a Model of Hyperhomocysteinemia | Zendy

Amany Tawfik | Zendy; Mohamed AlShabrawey | Zendy; Penny Roon | Zendy; Srinivas Sonne | Zendy; Jason Covar | Zendy; Surapoon Matragoon | Zendy; Preethi S. Ganapathy | Zendy; Sally S. Atherton | Zendy; Azza B. ElRemessy | Zendy; Vadivel Ganapathy | Zendy; Sylvia B. Smith | Zendy

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Alterations of Retinal Vasculature in Cystathionine-Beta-Synthase Mutant Mice, a Model of Hyperhomocysteinemia

Author(s) -

Amany Tawfik,

Mohamed AlShabrawey,

Penny Roon,

Srinivas Sonne,

Jason Covar,

Surapoon Matragoon,

Preethi S. Ganapathy,

Sally S. Atherton,

Azza B. ElRemessy,

Vadivel Ganapathy,

Sylvia B. Smith

Publication year - 2013

Publication title -

investigative ophthalmology and visual science

Language(s) - English

Resource type - Journals

eISSN - 1552-5783

pISSN - 0146-0404

DOI - 10.1167/iovs.12-10536

Subject(s) - cystathionine beta synthase , retinal , occludin , glial fibrillary acidic protein , hyperhomocysteinemia , biology , homocysteine , retina , blood–retinal barrier , pathology , microbiology and biotechnology , endocrinology , tight junction , biochemistry , medicine , methionine , immunology , immunohistochemistry , diabetic retinopathy , amino acid , neuroscience , diabetes mellitus

Mice with moderate/severe hyperhomocysteinemia due to deficiency or absence of the cbs gene encoding cystathionine-beta-synthase (CBS) have marked retinal disruption, ganglion cell loss, optic nerve mitochondrial dysfunction, and ERG defects; those with mild hyperhomocysteinemia have delayed retinal morphological/functional phenotype. Excess homocysteine is a risk factor for cardiovascular diseases; however, it is not known whether excess homocysteine alters retinal vasculature.

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