Mitochondrial Dynamics Regulate Growth Cone Motility, Guidance, and Neurite Growth Rate in Perinatal Retinal Ganglion Cells In Vitro | Zendy

Michael B. Steketee | Zendy; Stavros N. Moysidis | Zendy; Jessica E. Weinstein | Zendy; Alexander Kreymerman | Zendy; José P. Silva | Zendy; Siraj Iqbal | Zendy; Jeffrey L. Goldberg | Zendy

Open Access

Mitochondrial Dynamics Regulate Growth Cone Motility, Guidance, and Neurite Growth Rate in Perinatal Retinal Ganglion Cells In Vitro

Author(s) -

Michael B. Steketee,

Stavros N. Moysidis,

Jessica E. Weinstein,

Alexander Kreymerman,

José P. Silva,

Siraj Iqbal,

Jeffrey L. Goldberg

Publication year - 2012

Publication title -

investigative ophthalmology and visual science

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.935

H-Index - 218

eISSN - 1552-5783

pISSN - 0146-0404

DOI - 10.1167/iovs.12-10298

Subject(s) - neurite , growth cone , microbiology and biotechnology , biology , retinal ganglion cell , chondroitin sulfate proteoglycan , mitochondrion , axon , retina , neuroscience , proteoglycan , biochemistry , in vitro , extracellular matrix

Retinal ganglion cell (RGC) death and failed axonal regeneration after trauma or disease, including glaucomatous and mitochondrial optic neuropathies, are linked increasingly to dysfunctional mitochondrial dynamics. However, how mitochondrial dynamics influence axon growth largely is unstudied. We examined intrinsic mitochondrial organization in embryonic and postnatal RGCs and the roles that mitochondrial dynamics have in regulating neurite growth and guidance.

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