Open AccessInnate Immune Regulation ofSerratia marcescens–Induced Corneal Inflammation and Infection
Author(s) -
Rong Zhou,
Rui Zhang,
Yan Sun,
Sean Platt,
Loretta Szczotka-Flynn,
Eric Pearlman
Publication year - 2012
Publication title -
investigative ophthalmology and visual science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.935
H-Index - 218
eISSN - 1552-5783
pISSN - 0146-0404
DOI - 10.1167/iovs.12-10238
Subject(s) - serratia marcescens , innate immune system , inflammation , immunology , microbiology and biotechnology , immune system , medicine , biology , escherichia coli , biochemistry , gene
Serratia marcescens is frequently isolated from lenses of patients with contact lens-associated corneal infiltrates. In the current study, we examined the role of toll-like receptors (TLRs) and interleukin-1 receptor type 1 (IL-1R1) in S. marcescens-induced corneal inflammation and infection.