A Role for Jag2 in Promoting Uveal Melanoma Dissemination and Growth | Zendy

Laura Asnaghi | Zendy; James T. Handa | Zendy; Shannath L. Merbs | Zendy; J. William Harbour | Zendy; Charles G. Eberhart | Zendy

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A Role for Jag2 in Promoting Uveal Melanoma Dissemination and Growth

Author(s) -

Laura Asnaghi,

James T. Handa,

Shannath L. Merbs,

J. William Harbour,

Charles G. Eberhart

Publication year - 2012

Publication title -

investigative ophthalmology and visual science

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.935

H-Index - 218

eISSN - 1552-5783

pISSN - 0146-0404

DOI - 10.1167/iovs.12-10209

Subject(s) - notch signaling pathway , jag1 , cancer research , biology , melanoma , clonogenic assay , downregulation and upregulation , microbiology and biotechnology , cell culture , genetics , gene , signal transduction

Controlling the spread of uveal melanoma is key to improving survival of patients with this common intraocular malignancy. The Notch ligand Jag2 has been shown to be upregulated in primary tumors that metastasize, and we therefore investigated its role in promoting invasion and clonogenic growth of uveal melanoma cells.

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