Microarray Analysis of Murine Retinal Light Damage Reveals Changes in Iron Regulatory, Complement, and Antioxidant Genes in the Neurosensory Retina and Isolated RPE
Author(s) -
Majda Hadziahmetovic,
Usha Kumar,
Ying Song,
Steven F. Grieco,
Delu Song,
Yafeng Li,
John W. Tobias,
Joshua L. Dunaief
Publication year - 2012
Publication title -
investigative ophthalmology and visual science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.935
H-Index - 218
eISSN - 1552-5783
pISSN - 0146-0404
DOI - 10.1167/iovs.12-10204
Subject(s) - retina , retinal , microarray analysis techniques , complement (music) , microarray , biology , gene , microbiology and biotechnology , ophthalmology , genetics , neuroscience , medicine , phenotype , gene expression , complementation
The purpose of this study was to investigate light damage-induced transcript changes within neurosensory retina (NSR) and isolated retinal pigment epithelium (RPE). Similar studies have been conducted previously, but were usually limited to the NSR and only a portion of the transcriptome. Herein most of the transcriptome, not just in the NSR but also in isolated RPE, was queried.
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