Open AccessAnti-Inflammatory Effects of Lutein in Retinal Ischemic/Hypoxic Injury: In Vivo and In Vitro Studies
Author(s) -
Suk-Yee Li,
Francis Fung,
Zhongjie Fu,
David Wong,
Ho Lung Henry Chan,
Amy Cheuk Yin Lo
Publication year - 2012
Publication title -
investigative ophthalmology and visual science
Language(s) - English
Resource type - Journals
eISSN - 1552-5783
pISSN - 0146-0404
DOI - 10.1167/iovs.12-10007
Subject(s) - lutein , retinal , glial fibrillary acidic protein , reperfusion injury , inflammation , gliosis , retina , microglia , electroretinography , chemistry , ischemia , endocrinology , biology , pharmacology , immunology , medicine , pathology , biochemistry , neuroscience , immunohistochemistry , carotenoid
Lutein protects retinal neurons by its anti-oxidative and anti-apoptotic properties in ischemia/reperfusion (I/R) injury while its anti-inflammatory effects remain unknown. As Müller cells play a critical role in retinal inflammation, the effect of lutein on Müller cells was investigated in a murine model of I/R injury and a culture model of hypoxic damage.