Integrin-Linked Kinase Deletion in the Developing Lens Leads to Capsule Rupture, Impaired Fiber Migration and Non-Apoptotic Epithelial Cell Death | Zendy

Laura Cammas | Zendy; Jordan Wolfe | Zendy; SueYeon Choi | Zendy; Shoukat Dedhar | Zendy; Hilary E. Beggs | Zendy

Open Access

Integrin-Linked Kinase Deletion in the Developing Lens Leads to Capsule Rupture, Impaired Fiber Migration and Non-Apoptotic Epithelial Cell Death

Author(s) -

Laura Cammas,

Jordan Wolfe,

SueYeon Choi,

Shoukat Dedhar,

Hilary E. Beggs

Publication year - 2012

Publication title -

investigative ophthalmology and visual science

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.935

H-Index - 218

eISSN - 1552-5783

pISSN - 0146-0404

DOI - 10.1167/iovs.11-9128

Subject(s) - integrin linked kinase , microbiology and biotechnology , extracellular matrix , tunel assay , biology , focal adhesion , programmed cell death , apoptosis , anoikis , kinase , signal transduction , protein kinase a , biochemistry , cyclin dependent kinase 2

The lens is a powerful model system to study integrin-mediated cell-matrix interaction in an in vivo context, as it is surrounded by a true basement membrane, the lens capsule. To characterize better the function of integrin-linked kinase (ILK), we examined the phenotypic consequences of its deletion in the developing mouse lens.

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