Open AccessCompound 49b Prevents Diabetes-Induced Apoptosis through Increased IGFBP-3 Levels
Author(s) -
Qiuhua Zhang,
Kimberly Guy,
Jayaprakash Pagadala,
Youde Jiang,
Robert J. Walker,
Luhong Liu,
Carl Soderland,
Timothy S. Kern,
Robert J. Ferry,
Hui He,
Charles R. Yates,
Duane D. Miller,
Jena J. Steinle
Publication year - 2012
Publication title -
investigative ophthalmology and visual science
Language(s) - Uncategorized
Resource type - Journals
SCImago Journal Rank - 1.935
H-Index - 218
eISSN - 1552-5783
pISSN - 0146-0404
DOI - 10.1167/iovs.11-8779
Subject(s) - retinal , retina , pericyte , ganglion cell layer , endocrinology , apoptosis , medicine , biology , electroretinography , endothelial stem cell , in vitro , biochemistry , neuroscience
To determine whether Compound 49b, a novel PKA-activating drug, can prevent diabetic-like changes in the rat retina through increased insulin-like growth factor binding protein-3 (IGFBP-3) levels.