Acute Retinal Ischemia Inhibits Endothelium-Dependent Nitric Oxide–Mediated Dilation of Retinal Arterioles via Enhanced Superoxide Production | Zendy

Travis W. Hein | Zendy; Yi Ren | Zendy; Luke B. Potts | Zendy; Zhaoxu Yuan | Zendy; Enoch Kuo | Zendy; Robert H. Rosa | Zendy; Lih Kuo | Zendy

Open Access

Acute Retinal Ischemia Inhibits Endothelium-Dependent Nitric Oxide–Mediated Dilation of Retinal Arterioles via Enhanced Superoxide Production

Author(s) -

Travis W. Hein,

Yi Ren,

Luke B. Potts,

Zhaoxu Yuan,

Enoch Kuo,

Robert H. Rosa,

Lih Kuo

Publication year - 2011

Publication title -

investigative ophthalmology and visual science

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.935

H-Index - 218

eISSN - 1552-5783

pISSN - 0146-0404

DOI - 10.1167/iovs.11-8753

Subject(s) - retinal , bradykinin , superoxide , nitric oxide , ischemia , vasodilation , medicine , sodium nitroprusside , chemistry , endocrinology , pharmacology , anesthesia , ophthalmology , biochemistry , receptor , enzyme

Because retinal vascular disease is associated with ischemia and increased oxidative stress, the vasodilator function of retinal arterioles was examined after retinal ischemia induced by elevated intraocular pressure (IOP). The role of superoxide anions in the development of vascular dysfunction was assessed.

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