Vitreous IGFBP-3 Effects on Müller Cell Proliferation and Tractional Force Generation | Zendy

Jeffery L. King | Zendy; Clyde Guidry | Zendy

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Vitreous IGFBP-3 Effects on Müller Cell Proliferation and Tractional Force Generation

Author(s) -

Jeffery L. King,

Clyde Guidry

Publication year - 2011

Publication title -

investigative ophthalmology and visual science

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.935

H-Index - 218

eISSN - 1552-5783

pISSN - 0146-0404

DOI - 10.1167/iovs.11-8683

Subject(s) - growth factor , platelet derived growth factor receptor , proliferative vitreoretinopathy , insulin like growth factor , cell growth , extracellular matrix , platelet derived growth factor , insulin like growth factor binding protein , microbiology and biotechnology , chemistry , cell , biology , medicine , endocrinology , receptor , biochemistry , retinal , retinal detachment

Previous studies from this laboratory revealed that vitreous insulin-like growth factor binding protein-3 (IGFBP-3) is a biologically active fragment of the intact protein. The goal of this study was to characterize its effects on Müller cell proliferation and tractional force generation, activities relevant to proliferative diabetic retinopathy (PDR).

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