Hydrocortisone Stimulates Neurite Outgrowth from Mouse Retinal Explants by Modulating Macroglial Activity | Zendy

Kimberly A. Toops | Zendy; Cynthia Berlinicke | Zendy; Donald J. Zack | Zendy; Robert W. Nickells | Zendy

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Hydrocortisone Stimulates Neurite Outgrowth from Mouse Retinal Explants by Modulating Macroglial Activity

Author(s) -

Kimberly A. Toops,

Cynthia Berlinicke,

Donald J. Zack,

Robert W. Nickells

Publication year - 2012

Publication title -

investigative ophthalmology and visual science

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.935

H-Index - 218

eISSN - 1552-5783

pISSN - 0146-0404

DOI - 10.1167/iovs.11-8646

Subject(s) - neurite , explant culture , ciliary neurotrophic factor , regeneration (biology) , microbiology and biotechnology , neurotrophic factors , neuroprotection , neurotrophin , nerve growth factor , biology , chemistry , in vitro , neuroscience , biochemistry , receptor

There is mounting evidence that retinal ganglion cells (RGCs) require a complex milieu of trophic factors to enhance cell survival and axon regeneration after optic nerve injury. The authors' goal was to examine the contribution of components of a combination of hormones, growth factors, steroids, and small molecules to creating a regenerative environment and to determine if any of these components modulated macroglial behavior to aid in regeneration.

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