Open AccessAttenuation of EphrinB2 Reverse Signaling Decreases Vascularized Area and Preretinal Vascular Tuft Formation in the Murine Model of Oxygen-Induced Retinopathy
Author(s) -
Alyssa Catherine Taylor,
Thomas Mendel,
Katelyn E. Mason,
Katherine Degen,
Paul Yates,
Shayn M. Peirce
Publication year - 2012
Publication title -
investigative ophthalmology and visual science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.935
H-Index - 218
eISSN - 1552-5783
pISSN - 0146-0404
DOI - 10.1167/iovs.11-8599
Subject(s) - retinal , sprouting angiogenesis , angiogenesis , neovascularization , retinopathy , biology , microbiology and biotechnology , retina , cancer research , endocrinology , neuroscience , biochemistry , diabetes mellitus
EphB4 and ephrinB2 are known key regulators of retinal vascular development, but due to their capacity for bidirectional signaling, delineation of their individual roles in this process remains unclear. To better dissect out individual contributions, a model of proliferative retinopathy in mice with attenuated ephrinB2 reverse signaling was studied. It was hypothesized that endothelial ephrinB2 reverse signaling regulates hypoxia-induced capillary sprouting, as well as the pathologic formation of neovascular tufts in postnatal retinal microvascular networks.