Differences in Human Meibum Lipid Composition with Meibomian Gland Dysfunction Using NMR and Principal Component Analysis | Zendy

Douglas Borchman | Zendy; Gary N. Foulks | Zendy; Marta C. Yappert | Zendy; Sarah E. Milliner | Zendy

Open Access

Differences in Human Meibum Lipid Composition with Meibomian Gland Dysfunction Using NMR and Principal Component Analysis

Author(s) -

Douglas Borchman,

Gary N. Foulks,

Marta C. Yappert,

Sarah E. Milliner

Publication year - 2011

Publication title -

investigative ophthalmology and visual science

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.935

H-Index - 218

eISSN - 1552-5783

pISSN - 0146-0404

DOI - 10.1167/iovs.11-8551

Subject(s) - chemistry , meibomian gland , wax , nuclear magnetic resonance spectroscopy , principal component analysis , proton nmr , cholesterol , terpenoid , carbon 13 nmr , nmr spectra database , chromatography , biochemistry , organic chemistry , spectral line , medicine , physics , surgery , astronomy , artificial intelligence , eyelid , computer science

Nuclear magnetic resonance (NMR) spectroscopy has been used to quantify lipid wax, cholesterol ester terpenoid and glyceride composition, saturation, oxidation, and CH₂ and CH₃ moiety distribution. This tool was used to measure changes in human meibum composition with meibomian gland dysfunction (MGD).

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