Open AccessRetinoid Content, Visual Responses, and Ocular Morphology Are Compromised in the Retinas of Mice Lacking the Retinol-Binding Protein Receptor, STRA6
Author(s) -
Alexis Lorenzo Ruíz,
Manuel Mark,
Hugues Jacobs,
Muriel Klopfenstein,
Jane Hu,
Monte Lloyd,
Samer Habib,
Chinatsu Tosha,
Roxana A. Radu,
Norbert B. Ghyselinck,
Steven Nusinowitz,
Dean Bok
Publication year - 2012
Publication title -
investigative ophthalmology and visual science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.935
H-Index - 218
eISSN - 1552-5783
pISSN - 0146-0404
DOI - 10.1167/iovs.11-8476
Subject(s) - retina , retinoid , biology , retinol , immunocytochemistry , endocrinology , retinal , medicine , chemistry , retinoic acid , biochemistry , cell culture , neuroscience , vitamin , genetics
We report generation of a mouse model in which the STRA6 gene has been disrupted functionally to facilitate the study of visual responses, changes in ocular morphology, and retinoid processing under STRA6 protein deficiency.