Dependence of Corneal Stem/Progenitor Cells on Ocular Surface Innervation | Zendy

Hiroki Ueno | Zendy; Giulio Ferrari | Zendy; Takaaki Hattori | Zendy; Daniel R. Saban | Zendy; Kishore Reddy Katikireddy | Zendy; Sunil K. Chauhan | Zendy; Reza Dana | Zendy

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Dependence of Corneal Stem/Progenitor Cells on Ocular Surface Innervation

Author(s) -

Hiroki Ueno,

Giulio Ferrari,

Takaaki Hattori,

Daniel R. Saban,

Kishore Reddy Katikireddy,

Sunil K. Chauhan,

Reza Dana

Publication year - 2012

Publication title -

investigative ophthalmology and visual science

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.935

H-Index - 218

eISSN - 1552-5783

pISSN - 0146-0404

DOI - 10.1167/iovs.11-8438

Subject(s) - stem cell , progenitor cell , population , immunostaining , hes1 , biology , pathology , microbiology and biotechnology , anatomy , immunology , medicine , immunohistochemistry , notch signaling pathway , signal transduction , environmental health

Neurotrophic keratopathy (NK) is a corneal degeneration associated with corneal nerve dysfunction. It can cause corneal epithelial defects, stromal thinning, and perforation. However, it is not clear if and to which extent epithelial stem cells are affected in NK. The purpose of this study was to identify the relationship between corneolimbal epithelial progenitor/stem cells and sensory nerves using a denervated mouse model of NK.

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