Expression and Role of VEGF in the Adult Retinal Pigment Epithelium | Zendy

Knatokie M. Ford | Zendy; Magali SaintGeniez | Zendy; Tony E. Walshe | Zendy; Alisar S. Zahr | Zendy; Patricia A. D’Amore | Zendy

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Expression and Role of VEGF in the Adult Retinal Pigment Epithelium

Author(s) -

Knatokie M. Ford,

Magali SaintGeniez,

Tony E. Walshe,

Alisar S. Zahr,

Patricia A. D’Amore

Publication year - 2011

Publication title -

investigative ophthalmology and visual science

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.935

H-Index - 218

eISSN - 1552-5783

pISSN - 0146-0404

DOI - 10.1167/iovs.11-8353

Subject(s) - retinal pigment epithelium , vascular endothelial growth factor , macular degeneration , retina , angiogenesis , retinal , biology , vascular endothelial growth factor a , apoptosis , pathology , cancer research , medicine , vegf receptors , ophthalmology , neuroscience , biochemistry

Despite a lack of active angiogenesis, VEGF is expressed in nearly every adult tissue, and recent evidence suggests that VEGF may serve as a survival factor for both vascular and nonvascular tissues. VEGF blockade is a widely used treatment for neovascular diseases such as wet age-related macular degeneration (AMD). Therefore, it was sought in this study to evaluate the expression and role of endogenous VEGF in RPE.

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