Open AccessEffects of Proinflammatory Cytokines on the Claudin-19 Rich Tight Junctions of Human Retinal Pigment Epithelium
Author(s) -
Shaomin Peng,
Geliang Gan,
Veena S. Rao,
Ron A. Adelman,
Lawrence J. Rizzolo
Publication year - 2012
Publication title -
investigative ophthalmology and visual science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.935
H-Index - 218
eISSN - 1552-5783
pISSN - 0146-0404
DOI - 10.1167/iovs.11-8311
Subject(s) - tight junction , occludin , claudin , proinflammatory cytokine , microbiology and biotechnology , retinal pigment epithelium , tumor necrosis factor alpha , retinal , chemistry , cell junction , blood–retinal barrier , inflammation , biophysics , biology , immunology , endocrinology , biochemistry , cell , diabetic retinopathy , diabetes mellitus
Chronic, subclinical inflammation contributes to the pathogenesis of several ocular diseases, including age-related macular degeneration. Proinflammatory cytokines affect tight junctions in epithelia that lack claudin-19, but in the retinal pigment epithelium claudin-19 predominates. We examined the effects of cytokines on the tight junctions of human fetal RPE (hfRPE).