Effects of Proinflammatory Cytokines on the Claudin-19 Rich Tight Junctions of Human Retinal Pigment Epithelium | Zendy

Shaomin Peng | Zendy; Geliang Gan | Zendy; Veena Rao | Zendy; Ron A. Adelman | Zendy; Lawrence J. Rizzolo | Zendy

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Effects of Proinflammatory Cytokines on the Claudin-19 Rich Tight Junctions of Human Retinal Pigment Epithelium

Author(s) -

Shaomin Peng,

Geliang Gan,

Veena Rao,

Ron A. Adelman,

Lawrence J. Rizzolo

Publication year - 2012

Publication title -

investigative ophthalmology and visual science

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.935

H-Index - 218

eISSN - 1552-5783

pISSN - 0146-0404

DOI - 10.1167/iovs.11-8311

Subject(s) - tight junction , occludin , claudin , proinflammatory cytokine , microbiology and biotechnology , retinal pigment epithelium , tumor necrosis factor alpha , retinal , chemistry , cell junction , blood–retinal barrier , inflammation , biophysics , biology , immunology , endocrinology , biochemistry , cell , diabetic retinopathy , diabetes mellitus

Chronic, subclinical inflammation contributes to the pathogenesis of several ocular diseases, including age-related macular degeneration. Proinflammatory cytokines affect tight junctions in epithelia that lack claudin-19, but in the retinal pigment epithelium claudin-19 predominates. We examined the effects of cytokines on the tight junctions of human fetal RPE (hfRPE).

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