Intraocular Safety and Pharmacokinetics of Hexadecyloxypropyl-Cidofovir (HDP-CDV) as a Long-lasting Intravitreal Antiviral Drug | Zendy

Haiyan Wang | Zendy; Jay Chhablani | Zendy; William R. Freeman | Zendy; James R. Beadle | Zendy; Karl Y. Hostetler | Zendy; Kathrin Hartmann | Zendy; Laura Conner | Zendy; Kathy A. Aldern | Zendy; Lindsey Pearson | Zendy; Lingyun Cheng | Zendy

Open Access

Intraocular Safety and Pharmacokinetics of Hexadecyloxypropyl-Cidofovir (HDP-CDV) as a Long-lasting Intravitreal Antiviral Drug

Author(s) -

Haiyan Wang,

Jay Chhablani,

William R. Freeman,

James R. Beadle,

Karl Y. Hostetler,

Kathrin Hartmann,

Laura Conner,

Kathy A. Aldern,

Lindsey Pearson,

Lingyun Cheng

Publication year - 2011

Publication title -

investigative ophthalmology and visual science

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.935

H-Index - 218

eISSN - 1552-5783

pISSN - 0146-0404

DOI - 10.1167/iovs.11-8293

Subject(s) - cidofovir , pharmacokinetics , prodrug , metabolite , choroid , cytomegalovirus retinitis , retinitis , active metabolite , pharmacology , antiviral drug , chemistry , medicine , retina , virology , human cytomegalovirus , virus , biology , drug , biochemistry , neuroscience

To evaluate the intraocular safety and pharmacokinetics of hexadecyloxypropyl-cidofovir (HDP-CDV), the hydrolysis product of HDP-cyclic-CDV, a long-lasting intravitreal cidofovir prodrug for cytomegalovirus (CMV) retinitis.

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