Human Corneal Endothelial Cells Employ Phosphorylation of p27Kip1at Both Ser10 and Thr187 Sites for FGF-2-Mediated Cell Proliferation via PI 3-Kinase | Zendy

Jung Goo Lee | Zendy; Jong-Suk Song | Zendy; Ronald E. Smith | Zendy; EunDuck P. Kay | Zendy

Open Access

Human Corneal Endothelial Cells Employ Phosphorylation of p27^Kip1at Both Ser10 and Thr187 Sites for FGF-2-Mediated Cell Proliferation via PI 3-Kinase

Author(s) -

Jung Goo Lee,

Jong-Suk Song,

Ronald E. Smith,

EunDuck P. Kay

Publication year - 2011

Publication title -

investigative ophthalmology and visual science

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.935

H-Index - 218

eISSN - 1552-5783

pISSN - 0146-0404

DOI - 10.1167/iovs.11-8213

Subject(s) - kinase , phosphorylation , cell growth , microbiology and biotechnology , cell cycle , ly294002 , biology , signal transduction , mapk/erk pathway , chemistry , biochemistry , cell , protein kinase b

FGF-2 stimulates cell proliferation of rabbit corneal endothelial cells (rCECs) by degrading the cyclin-dependent kinase inhibitor p27(Kip1) (p27) through its phosphorylation mechanism. The authors investigated whether the cell proliferation of human CECs (hCECs) is also induced by FGF-2 stimulation through the p27 phosphorylation pathway.

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