Transduction, Tropism, and Biodistribution of AAV Vectors in the Lacrimal Gland | Zendy

Eduardo Melani Rocha | Zendy; Giovanni Di Pasquale | Zendy; Paola Pérez Riveros | Zendy; Kathrina Quinn | Zendy; Beverly Handelman | Zendy; John A. Chiorini | Zendy

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Transduction, Tropism, and Biodistribution of AAV Vectors in the Lacrimal Gland

Author(s) -

Eduardo Melani Rocha,

Giovanni Di Pasquale,

Paola Pérez Riveros,

Kathrina Quinn,

Beverly Handelman,

John A. Chiorini

Publication year - 2011

Publication title -

investigative ophthalmology and visual science

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.935

H-Index - 218

eISSN - 1552-5783

pISSN - 0146-0404

DOI - 10.1167/iovs.11-8171

Subject(s) - transduction (biophysics) , genetic enhancement , gene delivery , luciferase , microbiology and biotechnology , tropism , biodistribution , adeno associated virus , biology , signal transduction , immunohistochemistry , viral vector , virology , in vivo , vector (molecular biology) , gene , virus , immunology , transfection , genetics , biochemistry , recombinant dna

The lacrimal gland (LG) delivers defensive and metabolic factors to the ocular surface. These functions may be disrupted in several diseases, and for most of them there is no cure. The aim of this study is to investigate conditions and limitations for using adeno-associated virus (AAV) vectors as gene transfer agents to LG.

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