Late-Onset Inner Retinal Dysfunction in Mice Lacking Sigma Receptor 1 (σR1) | Zendy

Yonju Ha | Zendy; Alan Saul | Zendy; Amany Tawfik | Zendy; Cory Williams | Zendy; Kathryn Bollinger | Zendy; Robert G. Smith | Zendy; Masanori Tachikawa | Zendy; Eric P. Zorrilla | Zendy; Vadivel Ganapathy | Zendy; Sylvia B. Smith | Zendy

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Late-Onset Inner Retinal Dysfunction in Mice Lacking Sigma Receptor 1 (σR1)

Author(s) -

Yonju Ha,

Alan Saul,

Amany Tawfik,

Cory Williams,

Kathryn Bollinger,

Robert G. Smith,

Masanori Tachikawa,

Eric P. Zorrilla,

Vadivel Ganapathy,

Sylvia B. Smith

Publication year - 2011

Publication title -

investigative ophthalmology and visual science

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.935

H-Index - 218

eISSN - 1552-5783

pISSN - 0146-0404

DOI - 10.1167/iovs.11-8169

Subject(s) - retinal , retina , erg , scotopic vision , biology , optic nerve , electroretinography , retinal ganglion cell , inner nuclear layer , knockout mouse , endocrinology , anatomy , receptor , neuroscience , genetics , biochemistry

Sigma receptor 1 (σR1) is expressed abundantly in the eye, and several reports suggest that this putative molecular chaperone plays a role in lens cell survival, control of intraocular pressure (IOP), and retinal neuroprotection. The present study examined the consequence of the absence of σR1 on ocular development, structure, and function.

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