Open AccessDiabetic Retinopathy and Damage to Mitochondrial Structure and Transport Machinery
Author(s) -
Qing Zhong,
Renu A. Kowluru
Publication year - 2011
Publication title -
investigative ophthalmology and visual science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.935
H-Index - 218
eISSN - 1552-5783
pISSN - 0146-0404
DOI - 10.1167/iovs.11-8045
Subject(s) - mfn2 , mitochondrial fusion , mitochondrion , retinal , biology , mitochondrial fission , retina , diabetic retinopathy , western blot , mitochondrial dna , fis1 , endocrinology , microbiology and biotechnology , medicine , diabetes mellitus , gene , genetics , biochemistry , neuroscience
Mitochondrial function is controlled by membrane structure. In diabetes, retinal mitochondria are dysfunctional, and reversal of hyperglycemia fails to inhibit such changes. The goal of this study was to use anatomic and molecular biologic techniques to investigate the effect of diabetes on mitochondrial membrane structure.