Substratum Topography Modulates Corneal Fibroblast to Myofibroblast Transformation | Zendy

Kathern E. Myrna | Zendy; Rima Mendonsa | Zendy; Paul Russell | Zendy; Simon A. Pot | Zendy; Sara J. Liliensiek | Zendy; James V. Jester | Zendy; Paul F. Nealey | Zendy; Donald D. Brown | Zendy; Christopher J. Murphy | Zendy

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Substratum Topography Modulates Corneal Fibroblast to Myofibroblast Transformation

Author(s) -

Kathern E. Myrna,

Rima Mendonsa,

Paul Russell,

Simon A. Pot,

Sara J. Liliensiek,

James V. Jester,

Paul F. Nealey,

Donald D. Brown,

Christopher J. Murphy

Publication year - 2012

Publication title -

investigative ophthalmology and visual science

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.935

H-Index - 218

eISSN - 1552-5783

pISSN - 0146-0404

DOI - 10.1167/iovs.11-7982

Subject(s) - myofibroblast , fibroblast , western blot , blot , wound healing , immunocytochemistry , phenotype , microbiology and biotechnology , downregulation and upregulation , fibrosis , chemistry , pathology , biology , cell culture , medicine , immunology , biochemistry , gene , genetics

The transition of corneal fibroblasts to the myofibroblast phenotype is known to be important in wound healing. The purpose of this study was to determine the effect of topographic cues on TGFβ-induced myofibroblast transformation of corneal cells.

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