Open AccessDiffusion Tensor Imaging Detected Optic Nerve Injury Correlates with Decreased Compound Action Potentials after Murine Retinal Ischemia
Author(s) -
Qing Wang,
Roman Vlkolinský,
Meili Xie,
André Obenaus,
ShengKwei Song
Publication year - 2012
Publication title -
investigative ophthalmology and visual science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.935
H-Index - 218
eISSN - 1552-5783
pISSN - 0146-0404
DOI - 10.1167/iovs.11-7908
Subject(s) - optic nerve , ischemia , retinal , myelin , retina , fractional anisotropy , medicine , pathology , anatomy , diffusion mri , ophthalmology , biology , neuroscience , central nervous system , radiology , magnetic resonance imaging
This study evaluated the function of mouse optic nerves after transient retinal ischemia using in vitro electrophysiologic recordings of compound action potentials (CAPs) correlated with diffusion tensor imaging (DTI) injury markers with confirmation by immunohistochemistry-determined pathology.