In Vitro Models for Glaucoma Research: Effects of Hydrostatic Pressure | Zendy

Yuan Lei | Zendy; Shadi Rajabi | Zendy; Ryan M. Pedrigi | Zendy; Darryl R. Overby | Zendy; A. Thomas Read | Zendy; C. Ross Ethier | Zendy

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In Vitro Models for Glaucoma Research: Effects of Hydrostatic Pressure

Author(s) -

Yuan Lei,

Shadi Rajabi,

Ryan M. Pedrigi,

Darryl R. Overby,

A. Thomas Read,

C. Ross Ethier

Publication year - 2011

Publication title -

investigative ophthalmology and visual science

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.935

H-Index - 218

eISSN - 1552-5783

pISSN - 0146-0404

DOI - 10.1167/iovs.11-7836

Subject(s) - hydrostatic pressure , tension (geology) , chemistry , oxygen tension , intraocular pressure , biophysics , materials science , ophthalmology , oxygen , composite material , mechanics , biology , medicine , physics , organic chemistry , ultimate tensile strength

The response of cells (e.g., optic nerve head [ONH] cells) to mechanical stress is important in glaucoma. Studies have reported the biological effects of hydrostatic pressure on ONH cells cultured on a rigid substrate. An apparatus, designed to independently vary hydrostatic pressure and gas tension (including oxygen tension) in culture medium, was used to evaluate the effects of pressure and tension on cell migration, shape, and α-tubulin architecture in a transformed cell line (DITNC1 rat cortical astrocytes).

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