The High-Mobility Group Box-1 Nuclear Factor Mediates Retinal Injury after Ischemia Reperfusion | Zendy

Galina Dvoriantchikova | Zendy; Eleut Hernandez | Zendy; Jeff Grant | Zendy; Andrea Rachelle C. Santos | Zendy; Huan Yang | Zendy; Dmitry Ivanov | Zendy

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The High-Mobility Group Box-1 Nuclear Factor Mediates Retinal Injury after Ischemia Reperfusion

Author(s) -

Galina Dvoriantchikova,

Eleut Hernandez,

Jeff Grant,

Andrea Rachelle C. Santos,

Huan Yang,

Dmitry Ivanov

Publication year - 2011

Publication title -

investigative ophthalmology and visual science

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.935

H-Index - 218

eISSN - 1552-5783

pISSN - 0146-0404

DOI - 10.1167/iovs.11-7793

Subject(s) - hmgb1 , retina , rage (emotion) , retinal , retinal ganglion cell , proinflammatory cytokine , inner nuclear layer , ganglion cell layer , reperfusion injury , ischemia , microbiology and biotechnology , chemistry , medicine , pharmacology , biology , immunology , inflammation , ophthalmology , neuroscience

High-mobility group protein B1 (Hmgb1) is released from necrotic cells and induces an inflammatory response. Although Hmgb1 has been implicated in ischemia/reperfusion (IR) injury of the brain, its role in IR injury of the retina remains unclear. Here, the authors provide evidence that Hmgb1 contributes to retinal damage after IR.

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