Diabetes Diminishes Phosphatidic Acid in the Retina: A Putative Mediator for Reduced mTOR Signaling and Increased Neuronal Cell Death | Zendy

Todd E. Fox | Zendy; Megan M. Young | Zendy; Michelle M. Pedersen | Zendy; Xianlin Han | Zendy; Thomas W. Gardner | Zendy; Mark Kester | Zendy

Open Access

Diabetes Diminishes Phosphatidic Acid in the Retina: A Putative Mediator for Reduced mTOR Signaling and Increased Neuronal Cell Death

Author(s) -

Todd E. Fox,

Megan M. Young,

Michelle M. Pedersen,

Xianlin Han,

Thomas W. Gardner,

Mark Kester

Publication year - 2012

Publication title -

investigative ophthalmology and visual science

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.935

H-Index - 218

eISSN - 1552-5783

pISSN - 0146-0404

DOI - 10.1167/iovs.11-7626

Subject(s) - pi3k/akt/mtor pathway , p70 s6 kinase 1 , protein kinase b , biology , rptor , microbiology and biotechnology , signal transduction , insulin receptor , phosphatidic acid , insulin , mtorc1 , endocrinology , medicine , insulin resistance , biochemistry , phospholipid , membrane

We demonstrated previously that pro-survival insulin receptor, PI3K-Akt, and p70 S6K signaling is diminished in models of diabetic retinopathy. As mammalian target of rapamycin (mTOR), an upstream activator of p70 S6Kinase is, in part, regulated by lipid-derived second messengers, such as phosphatidic acid (PA), we sought to determine if diminished mTOR/p70 S6Kinase signaling in diabetic retinas may reflect diminished PA levels.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research