Diffusion Tensor Imaging Detects Retinal Ganglion Cell Axon Damage in the Mouse Model of Optic Nerve Crush | Zendy

Xu Zhang | Zendy; Peng Sun | Zendy; Jian Wang | Zendy; Qing Wang | Zendy; ShengKwei Song | Zendy

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Diffusion Tensor Imaging Detects Retinal Ganglion Cell Axon Damage in the Mouse Model of Optic Nerve Crush

Author(s) -

Xu Zhang,

Peng Sun,

Jian Wang,

Qing Wang,

ShengKwei Song

Publication year - 2011

Publication title -

investigative ophthalmology and visual science

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.935

H-Index - 218

eISSN - 1552-5783

pISSN - 0146-0404

DOI - 10.1167/iovs.11-7619

Subject(s) - retinal ganglion cell , optic nerve , axon , diffusion mri , ganglion , retina , anatomy , neuroscience , biology , medicine , magnetic resonance imaging , radiology

Diffusion tensor imaging (DTI) measures the random motion of water molecules reflecting central nervous system tissue integrity and pathology. Glaucoma damages retinal ganglion cells (RGCs) and their axons. The authors hypothesized that DTI-derived axonal and myelin injury biomarkers may be used to detect early axonal damage and may be correlated with RGC loss in the mouse model of optic nerve crush (ONC).

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