Open AccessRole of TGFβ/Smad Signaling in Gremlin Induction of Human Trabecular Meshwork Extracellular Matrix Proteins
Author(s) -
Anirudh Sethi,
Ankur Jain,
Gulab Zode,
Robert J. Wordinger,
Abbot F. Clark
Publication year - 2011
Publication title -
investigative ophthalmology and visual science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.935
H-Index - 218
eISSN - 1552-5783
pISSN - 0146-0404
DOI - 10.1167/iovs.11-7587
Subject(s) - ctgf , smad , trabecular meshwork , extracellular matrix , microbiology and biotechnology , bone morphogenetic protein , small interfering rna , transforming growth factor , signal transduction , chemistry , biology , growth factor , cell culture , gene , transfection , genetics , receptor , neuroscience , glaucoma
The bone morphogenic protein (BMP) antagonist gremlin is elevated in glaucomatous trabecular meshwork (TM) cells and tissues and elevates intraocular pressure (IOP). Gremlin also blocks BMP4 inhibition of transforming growth factor (TGF)-β2 induction of TM extracellular matrix (ECM) proteins. The purpose of this study was to determine whether Gremlin regulates ECM proteins in cultured human TM cells.