Inhibition of Mdm2 Sensitizes Human Retinal Pigment Epithelial Cells to Apoptosis | Zendy

Sujoy Bhattacharya | Zendy; Ramesh M. Ray | Zendy; Edward Chaum | Zendy; Dianna A. Johnson | Zendy; Leonard R. Johnson | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

Inhibition of Mdm2 Sensitizes Human Retinal Pigment Epithelial Cells to Apoptosis

Author(s) -

Sujoy Bhattacharya,

Ramesh M. Ray,

Edward Chaum,

Dianna A. Johnson,

Leonard R. Johnson

Publication year - 2011

Publication title -

investigative ophthalmology and visual science

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.935

H-Index - 218

eISSN - 1552-5783

pISSN - 0146-0404

DOI - 10.1167/iovs.10-6991

Subject(s) - apoptosis , puma , camptothecin , downregulation and upregulation , mdm2 , dna fragmentation , gene knockdown , caspase , microbiology and biotechnology , cycloheximide , biology , chemistry , programmed cell death , biochemistry , protein biosynthesis , gene

Because recent studies indicate that blocking the interaction between p53 and Mdm2 results in the nongenotoxic activation of p53, the authors sought to investigate whether the inhibition of p53-Mdm2 binding activates p53 and sensitizes human retinal epithelial cells to apoptosis.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research