Segmental Versican Expression in the Trabecular Meshwork and Involvement in Outflow Facility | Zendy

Kate E. Keller | Zendy; John M. Bradley | Zendy; Janice A. Vranka | Zendy; Ted S. Acott | Zendy

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Segmental Versican Expression in the Trabecular Meshwork and Involvement in Outflow Facility

Author(s) -

Kate E. Keller,

John M. Bradley,

Janice A. Vranka,

Ted S. Acott

Publication year - 2011

Publication title -

investigative ophthalmology and visual science

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.935

H-Index - 218

eISSN - 1552-5783

pISSN - 0146-0404

DOI - 10.1167/iovs.10-6948

Subject(s) - versican , trabecular meshwork , proteoglycan , gene silencing , chemistry , microbiology and biotechnology , outflow , glycosaminoglycan , biology , extracellular matrix , biochemistry , gene , neuroscience , physics , glaucoma , meteorology

Versican is a large proteoglycan with numerous chondroitin sulfate (CS) glycosaminoglycan (GAG) side chains attached. To assess versican's potential contributions to aqueous humor outflow resistance, its segmental distribution in the trabecular meshwork (TM) and the effect on outflow facility of silencing the versican gene were evaluated.

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