Role of Wall Teichoic Acids inStaphylococcus aureusEndophthalmitis | Zendy

Takashi Suzuki | Zendy; Jennifer Campbell | Zendy; Jonathan G. Swoboda | Zendy; Suzanne Walker | Zendy; Michael S. Gilmore | Zendy

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Role of Wall Teichoic Acids inStaphylococcus aureusEndophthalmitis

Author(s) -

Takashi Suzuki,

Jennifer Campbell,

Jonathan G. Swoboda,

Suzanne Walker,

Michael S. Gilmore

Publication year - 2011

Publication title -

investigative ophthalmology and visual science

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.935

H-Index - 218

eISSN - 1552-5783

pISSN - 0146-0404

DOI - 10.1167/iovs.10-6558

Subject(s) - staphylococcus aureus , teichoic acid , microbiology and biotechnology , endophthalmitis , virulence , leukocidin , biology , staphylococcal infections , in vitro , pathogen , bacteria , methicillin resistant staphylococcus aureus , biochemistry , genetics , gene

Wall teichoic acids (WTAs) are major polyanionic polymer components of the cell wall of Staphylococcus aureus. However, little is known about their role at the host-pathogen interface, especially in endophthalmitis. This study was designed to investigate the extent to which WTAs contribute to the pathogenicity of S. aureus in models of endophthalmitis and to determine whether there would be value in targeting their biosynthesis as a new therapeutic approach.

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