Resveratrol Inhibits Pathologic Retinal Neovascularization inVldlr−/−Mice | Zendy

Jing Hua | Zendy; Karen I. Guerin | Zendy; Jing Chen | Zendy; Shaday Michán | Zendy; Andreas Stahl | Zendy; Nathan M. Krah | Zendy; Molly R. Seaward | Zendy; Roberta J. Dennison | Zendy; Aimee M. Juan | Zendy; Colman J. Hatton | Zendy; Przemysław Sapieha | Zendy; David Sinclair | Zendy; Lois E. H. Smith | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

Resveratrol Inhibits Pathologic Retinal Neovascularization inVldlr^−/−Mice

Author(s) -

Jing Hua,

Karen I. Guerin,

Jing Chen,

Shaday Michán,

Andreas Stahl,

Nathan M. Krah,

Molly R. Seaward,

Roberta J. Dennison,

Aimee M. Juan,

Colman J. Hatton,

Przemysław Sapieha,

David Sinclair,

Lois E. H. Smith

Publication year - 2011

Publication title -

investigative ophthalmology and visual science

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.935

H-Index - 218

eISSN - 1552-5783

pISSN - 0146-0404

DOI - 10.1167/iovs.10-6496

Subject(s) - resveratrol , retinal , chemistry , neovascularization , choroidal neovascularization , ophthalmology , pharmacology , medicine , cancer research , biochemistry , angiogenesis

Macular telangiectasia (MacTel) is a vision-threatening retinal disease with unknown pathogenesis and no approved treatment. Very low-density lipoprotein receptor mutant mice (Vldlr(-/-)) exhibit critical features of MacTel such as retinal neovascularization and photoreceptor degeneration. In this study, the authors evaluate the therapeutic potential of resveratrol, a plant polyphenol, in Vldlr(-/-) mice as a model for MacTel.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research