Open AccessDisruption of Contact Lens–AssociatedPseudomonas aeruginosaBiofilms Formed in the Presence of Neutrophils
Author(s) -
Danielle M. Robertson,
Quinn M. Parks,
Robert L. Young,
Jennifer E. Kret,
Katie R. Poch,
Kenneth C. Malcolm,
David P. Nichols,
Michelle Nichols,
Meifang Zhu,
Harrison D Cavanagh,
Jerry A. Nick
Publication year - 2011
Publication title -
investigative ophthalmology and visual science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.935
H-Index - 218
eISSN - 1552-5783
pISSN - 0146-0404
DOI - 10.1167/iovs.10-6469
Subject(s) - biofilm , contact lens , microbiology and biotechnology , pseudomonas aeruginosa , chemistry , in vivo , corneal epithelium , epithelium , biology , bacteria , medicine , genetics , ophthalmology
To evaluate the capacity of neutrophils to enhance biofilm formation on contact lenses by an infectious Pseudomonas aeruginosa (PA) corneal isolate. Agents that target F-actin and DNA were tested as a therapeutic strategy for disrupting biofilms formed in the setting of neutrophils in vitro and for limiting the infectious bioburden in vivo.