Genetic Variants Associated with Optic Nerve Vertical Cup-to-Disc Ratio Are Risk Factors for Primary Open Angle Glaucoma in a US Caucasian Population | Zendy

Bao Jian Fan | Zendy; Dan Yi Wang | Zendy; Louis R. Pasquale | Zendy; Jonathan L. Haines | Zendy; Janey L. Wiggs | Zendy

Open Access

Genetic Variants Associated with Optic Nerve Vertical Cup-to-Disc Ratio Are Risk Factors for Primary Open Angle Glaucoma in a US Caucasian Population

Author(s) -

Bao Jian Fan,

Dan Yi Wang,

Louis R. Pasquale,

Jonathan L. Haines,

Janey L. Wiggs

Publication year - 2011

Publication title -

investigative ophthalmology and visual science

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.935

H-Index - 218

eISSN - 1552-5783

pISSN - 0146-0404

DOI - 10.1167/iovs.10-6339

Subject(s) - single nucleotide polymorphism , glaucoma , optic nerve , odds ratio , ophthalmology , optic disc , medicine , open angle glaucoma , genome wide association study , snp , population , allele , optic disk , genetic association , genotype , genetics , biology , gene , environmental health

Genetically complex disorders, such as primary open angle glaucoma (POAG), may include highly heritable quantitative traits as part of the overall phenotype, and mapping genes influencing the related quantitative traits may effectively identify genetic risk factors predisposing to the complex disease. Recent studies have identified SNPs associated with optic nerve area and vertical cup-to-disc ratio (VCDR). The purpose of this study was to evaluate the association between these SNPs and POAG in a US Caucasian case-control sample.

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